MovDisordV3, Main, Exploration, bibRecord, 001264

Brain biochemistry in autopsied patients with essential tremor

Identifieur interne : 001264 ( Main/Exploration ); précédent : 001263; suivant : 001265

Brain biochemistry in autopsied patients with essential tremor

Auteurs : Holly A. Shill ; Charles H. Adler ; Thomas G. Beach ; Lih-Fen Lue ; John N. Caviness ; Marwan N. Sabbagh ; Lucia I. Sue ; Douglas G. Walker

Source :

Movement Disorders [ 0885-3185 ] ; 2011.

RBID : PMC:3261329

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Autopsy, Brain (metabolism), Brain (pathology), Brain Chemistry, Cerebellum (metabolism), Corpus Striatum (metabolism), Dopamine beta-Hydroxylase (metabolism), Enzyme-Linked Immunosorbent Assay, Essential Tremor (metabolism), Essential Tremor (pathology), Female, Humans, Locus Coeruleus (metabolism), Male, Parvalbumins (metabolism), Tyrosine 3-Monooxygenase (metabolism).
MESH :
- chemical , metabolism : Dopamine beta-Hydroxylase, Parvalbumins, Tyrosine 3-Monooxygenase.
- metabolism : Brain, Cerebellum, Corpus Striatum, Essential Tremor, Locus Coeruleus.
- pathology : Brain, Essential Tremor.
- Aged, Aged, 80 and over, Autopsy, Brain Chemistry, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male.

Abstract

Background

The pathology of essential tremor is increasingly being studied; however, there are limited studies of biochemical changes in this condition.

Methods

We studied several candidate biochemical/anatomical systems in the brainstem, striatum and cerebellum of 23 essential tremor subjects who came to autopsy, comparing them to a control population.

Results

Striatal tyrosine hydroxylase, a marker of dopaminergic neurons, was 91.7 ±113.2 ng/mg versus 96.4±102.7 ng/mg (not significant) in cases and controls. Locus ceruleus dopamine beta-hydroxylase, a marker of noradrenergic neurons, was not significantly different between essential tremor and control groups. Parvalbumin, a marker of GABAergic neurons, was 199.3±42.0 versus 251.4±74.8 ng/mg (p=0.025) in the pons in the region of the locus ceruleus of essential tremor versus controls, while there was no difference in cerebellar parvalbumin.

Conclusion

These results are supportive of a possible role for reduced GABAergic function within the locus ceruleus in essential tremor. The hypothesis that essential tremor represents early Parkinson’s disease was not supported as striatal dopaminergic markers were not reduced compared to control subjects.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261329

DOI: 10.1002/mds.24004
PubMed: 22038525
PubMed Central: 3261329

Affiliations:

Le document en format XML

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<author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A." last="Shill">Holly A. Shill</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
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<author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H." last="Adler">Charles H. Adler</name>
<affiliation><nlm:aff id="A2">Mayo Clinic Arizona</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name>
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<author><name sortKey="Lue, Lih Fen" sort="Lue, Lih Fen" uniqKey="Lue L" first="Lih-Fen" last="Lue">Lih-Fen Lue</name>
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<author><name sortKey="Caviness, John N" sort="Caviness, John N" uniqKey="Caviness J" first="John N." last="Caviness">John N. Caviness</name>
<affiliation><nlm:aff id="A2">Mayo Clinic Arizona</nlm:aff>
</affiliation>
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<author><name sortKey="Sabbagh, Marwan N" sort="Sabbagh, Marwan N" uniqKey="Sabbagh M" first="Marwan N." last="Sabbagh">Marwan N. Sabbagh</name>
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<author><name sortKey="Sue, Lucia I" sort="Sue, Lucia I" uniqKey="Sue L" first="Lucia I" last="Sue">Lucia I. Sue</name>
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<author><name sortKey="Walker, Douglas G" sort="Walker, Douglas G" uniqKey="Walker D" first="Douglas G." last="Walker">Douglas G. Walker</name>
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<author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H." last="Adler">Charles H. Adler</name>
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<author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
</affiliation>
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<author><name sortKey="Lue, Lih Fen" sort="Lue, Lih Fen" uniqKey="Lue L" first="Lih-Fen" last="Lue">Lih-Fen Lue</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
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<author><name sortKey="Caviness, John N" sort="Caviness, John N" uniqKey="Caviness J" first="John N." last="Caviness">John N. Caviness</name>
<affiliation><nlm:aff id="A2">Mayo Clinic Arizona</nlm:aff>
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<author><name sortKey="Sabbagh, Marwan N" sort="Sabbagh, Marwan N" uniqKey="Sabbagh M" first="Marwan N." last="Sabbagh">Marwan N. Sabbagh</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
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<author><name sortKey="Sue, Lucia I" sort="Sue, Lucia I" uniqKey="Sue L" first="Lucia I" last="Sue">Lucia I. Sue</name>
<affiliation><nlm:aff id="A1">Banner Sun Health Research Institute</nlm:aff>
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<author><name sortKey="Walker, Douglas G" sort="Walker, Douglas G" uniqKey="Walker D" first="Douglas G." last="Walker">Douglas G. Walker</name>
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<series><title level="j">Movement Disorders</title>
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<term>Aged, 80 and over</term>
<term>Autopsy</term>
<term>Brain (metabolism)</term>
<term>Brain (pathology)</term>
<term>Brain Chemistry</term>
<term>Cerebellum (metabolism)</term>
<term>Corpus Striatum (metabolism)</term>
<term>Dopamine beta-Hydroxylase (metabolism)</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Essential Tremor (metabolism)</term>
<term>Essential Tremor (pathology)</term>
<term>Female</term>
<term>Humans</term>
<term>Locus Coeruleus (metabolism)</term>
<term>Male</term>
<term>Parvalbumins (metabolism)</term>
<term>Tyrosine 3-Monooxygenase (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine beta-Hydroxylase</term>
<term>Parvalbumins</term>
<term>Tyrosine 3-Monooxygenase</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term>
<term>Cerebellum</term>
<term>Corpus Striatum</term>
<term>Essential Tremor</term>
<term>Locus Coeruleus</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Essential Tremor</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Autopsy</term>
<term>Brain Chemistry</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">The pathology of essential tremor is increasingly being studied; however, there are limited studies of biochemical changes in this condition.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">We studied several candidate biochemical/anatomical systems in the brainstem, striatum and cerebellum of 23 essential tremor subjects who came to autopsy, comparing them to a control population.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Striatal tyrosine hydroxylase, a marker of dopaminergic neurons, was 91.7 ±113.2 ng/mg versus 96.4±102.7 ng/mg (not significant) in cases and controls. Locus ceruleus dopamine beta-hydroxylase, a marker of noradrenergic neurons, was not significantly different between essential tremor and control groups. Parvalbumin, a marker of GABAergic neurons, was 199.3±42.0 versus 251.4±74.8 ng/mg (p=0.025) in the pons in the region of the locus ceruleus of essential tremor versus controls, while there was no difference in cerebellar parvalbumin.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">These results are supportive of a possible role for reduced GABAergic function within the locus ceruleus in essential tremor. The hypothesis that essential tremor represents early Parkinson’s disease was not supported as striatal dopaminergic markers were not reduced compared to control subjects.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H." last="Adler">Charles H. Adler</name>
<name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name>
<name sortKey="Caviness, John N" sort="Caviness, John N" uniqKey="Caviness J" first="John N." last="Caviness">John N. Caviness</name>
<name sortKey="Lue, Lih Fen" sort="Lue, Lih Fen" uniqKey="Lue L" first="Lih-Fen" last="Lue">Lih-Fen Lue</name>
<name sortKey="Sabbagh, Marwan N" sort="Sabbagh, Marwan N" uniqKey="Sabbagh M" first="Marwan N." last="Sabbagh">Marwan N. Sabbagh</name>
<name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A." last="Shill">Holly A. Shill</name>
<name sortKey="Sue, Lucia I" sort="Sue, Lucia I" uniqKey="Sue L" first="Lucia I" last="Sue">Lucia I. Sue</name>
<name sortKey="Walker, Douglas G" sort="Walker, Douglas G" uniqKey="Walker D" first="Douglas G." last="Walker">Douglas G. Walker</name>
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Movement Disorders (revue)

Brain biochemistry in autopsied patients with essential tremor

Brain biochemistry in autopsied patients with essential tremor

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
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